Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Hongkui Deng0
Xiaomin Du0
Xiang Li0
Defang Liu0
Yantao Ma0
Date of Patent
June 25, 2024
0Patent Application Number
166185310
Date Filed
May 31, 2017
0Patent Citations
Patent Primary Examiner
Patent abstract
Provided are chemical inducers of lineage reprogramming (CiLR) which include glycogen synthase kinase inhibitors, TGFβ receptor inhibitors, cyclic AMP agonists or histone acetylators. Also provided is a method of inducing lineage reprograming in a partially or completely differentiated cell of a first type into a cell with characteristics of a second and different lineage. The method includes: contacting a cell with the CiLR for a sufficient period of time to result in reprograming the cell into a modified XEN-like cell which is subsequently programmed into a cell with characteristics of a second and different lineage.
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