Patent 12059452 was granted and assigned to Eli Lilly and Company on August, 2024 by the United States Patent and Trademark Office.
The present invention relates to fusion proteins comprising an insulin receptor agonist fused to a human IgG Fc region through the use of a peptide linker, and the use of such fusion proteins in the treatment of diabetes. The fusion protein of the present invention has an extended time action profile and is useful for providing basal glucose control for an extended period of time.