Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Taichi Kuramochi0
Shu Feng0
Noriyuki Takahashi0
Masaru Muraoka0
Date of Patent
September 10, 2024
0Patent Application Number
167631340
Date Filed
November 14, 2018
0Patent Citations
...
Patent Primary Examiner
Patent abstract
The invention provides anti-C1s antibodies and methods of using the same. The affinities of the antibodies to C1s depend on pH and other conditions. The invention also provides pharmaceutical formulations comprising the antibodies, and methods of treating an individual having a complement-mediated disease or disorder comprising administering the antibody to the individual. In addition, the binding affinity of the antibody at high and low pH was measured, and mice PK study was conducted on the antibodies, and pharmacokinetics parameters of the antibodies were evaluated in this application.
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