Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Claudia Racioppi0
Mathieu Desclaux0
Brian Zambrowicz0
Arijit Bhowmick0
Matthew Koss0
David Frendewey0
Marine Prissette0
John McWhirter0
Date of Patent
October 8, 2024
0Patent Application Number
185025160
Date Filed
November 6, 2023
0Patent Citations
Patent Primary Examiner
Patent abstract
BANF1, PPP2CA, and ANKLE2 were identified as genes that promote tau aggregation when disrupted. Improved tauopathy models such as cells, tissues, or animals having mutations in or inhibition of expression of BANF1 and/or PPP2CA and/or ANKLE2 are provided. Methods of using such improved tauopathy models for assessing therapeutic candidates for the treatment of a tauopathy, methods of making the improved tauopathy models, and methods of accelerating or exacerbating tau aggregation in a tauopathy model are also provided.
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