Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Mark D. Brigham0
Alexandra Trevino0
Feng Zhang0
Silvana Konermann0
Date of Patent
May 11, 2021
0Patent Application Number
154690810
Date Filed
March 24, 2017
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
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