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US Patent 12123033 Modified double-stranded donor templates

Patent 12123033 was granted and assigned to Integrated DNA Technologies on October, 2024 by the United States Patent and Trademark Office.

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Patent abstract

Described herein are compositions and methods for improving homology directed repair (HDR) efficiency and reducing homology-independent integration following introduction of double strand breaks with engineered nucleases. Additionally, modifications to double stranded DNA donors to improve the donor potency and efficiency of homology directed repair following introduction of double stranded breaks with programmable nucleases.

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