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US Patent 6852334 Cationic peg-lipids and methods of use

Patent 6852334 was granted and assigned to The University Of British Columbia on February, 2005 by the United States Patent and Trademark Office.

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Is a

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Patent attributes

Patent Applicant

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Current Assignee

The University Of British Columbia

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Lorne R. Palmer0

David B. Fenske0

Kim Wong0

Pieter R. Cullis0

Tao Chen0

Date of Patent

February 8, 2005

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Patent Application Number

095536390

Date Filed

April 20, 2000

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Patent Citations Received

US Patent 11801257 Stimulation of an immune response by enantiomers of cationic lipids

US Patent 11904015 Vaccine compositions and methods of use

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US Patent 11911359 Stimulation of an immune response by cationic lipids

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US Patent 11911465 Vaccine compositions and methods of use

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Patent Primary Examiner

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Patent abstract

The present invention provides cationic-polymer-lipid conjugates (CPLs) such as distal cationic-poly(ethylene glycol)-lipid conjugates which can be incorporated into conventional and stealth liposomes or other lipid-based formulation for enhancing cellular uptake. The CPLs of the present invention comprise a lipid moiety; a hydrophilic polymer; and a polycationic moiety. Method of increasing intracellular delivery of nucleic acids are also provided.

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