US Patent 6852334 Cationic peg-lipids and methods of use
Patent 6852334 was granted and assigned to The University Of British Columbia on February, 2005 by the United States Patent and Trademark Office.
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Patent abstract
The present invention provides cationic-polymer-lipid conjugates (CPLs) such as distal cationic-poly(ethylene glycol)-lipid conjugates which can be incorporated into conventional and stealth liposomes or other lipid-based formulation for enhancing cellular uptake. The CPLs of the present invention comprise a lipid moiety; a hydrophilic polymer; and a polycationic moiety. Method of increasing intracellular delivery of nucleic acids are also provided.
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Patent Inventor Names
David B. Fenske0
Kim Wong0
Lorne R. Palmer0
Pieter R. Cullis0
Tao Chen0
Date of Patent
February 8, 2005
0Patent Application Number
095536390
Date Filed
April 20, 2000
0Patent Primary Examiner
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US Patent 6852334 Cationic peg-lipids and methods of use
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