US Patent 6994982 Isolating biological modulators from biodiverse gene fragment libraries

The present invention provides a method for identifying a modulator or mediator of a biological activity, which activity includes antigenicity and or immunogenicity, said method comprising the step of:(i) producing a gene fragment expression library derived from defined nucleotide sequence fragments; and(ii) assaying the expression library for at least an amino acid sequence derived from step (i) for a biological activity wherein that activity is different from any activity the amino acid sequence may have in its native environment.