Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ralph M. Steinman0
Christian Muenz0
Date of Patent
February 28, 2006
0Patent Application Number
100493160
Date Filed
August 10, 2000
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to the identification of a subunit vaccine to prevent or treat infection of Epstein Barr Virus. In particular, EBNA-1 was identified as a vaccine antigen. In a specific embodiment, a purified protein corresponding to EBNA-1 elicited a strong CD4+ T cell response. The responsive CD4+ T cell are primarily TH1 in function. EBNA-1 is an attractive candidate for a protective vaccine against EBV, and for immunotherapy of EBV infection and neoplasms, particularly with dendritic cells charged with EBNA-1.
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