US Patent 7101540 Targeted retrograde gene delivery to motor neurons

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Patent Citations Received

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US Patent 12083188 Engineered DNA binding proteins

Edits on 6 Sep, 2023

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Patent Inventor Names

Brian K. Kaspar0

Fred H. Gage0

Edits on 31 Aug, 2023

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Golden AI

edited on 31 Aug, 2023

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Patent abstract

Methods are disclosed for delivering a heterologous gene to a cell body of a neuron by contacting a muscle tissue innervated by the neuron with a viral vector comprising a heterologous gene, wherein the viral vector enters said neuron and is retrogradely moved to the cell body. Additionally, methods for expressing secreted proteins from a nerve cell body as well as methods for treating neurodegenerative disorders such as amyotrophic lateral sclerosis are described.

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Official Website

https://pdfpiw.uspto.gov/.piw?Docid=071015400

Edits on 18 May, 2023

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