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US Patent 7105707 Process for preparing alkynyl-substituted aromatic and heterocyclic compounds

Patent 7105707 was granted and assigned to Pharmacore on September, 2006 by the United States Patent and Trademark Office.

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Patent abstract

Mono- and disubstituted aryl or heterocyclic acetylenes are produced by a process comprising reacting an aryl nitrile with an alkynylzinc compound, a bis-alkynylzinc compound, or an alkynylmagnesium compound, in the presence of a nickel/phosphine catalyst.

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