Patent 7105707 was granted and assigned to Pharmacore on September, 2006 by the United States Patent and Trademark Office.
Mono- and disubstituted aryl or heterocyclic acetylenes are produced by a process comprising reacting an aryl nitrile with an alkynylzinc compound, a bis-alkynylzinc compound, or an alkynylmagnesium compound, in the presence of a nickel/phosphine catalyst.