Patent 7160692 was granted and assigned to St. Jude Children's Research Hospital on January, 2007 by the United States Patent and Trademark Office.
The present invention provides methods for detecting activation of ATM kinase, DNA damage, and DNA damaging agents. Further provided are antibodies which specifically recognize the phosphorylation state of Ataxia Telangiectasia-Mutated (ATM) kinase. Methods of identifying agents which modulate the activation and activity of ATM kinase are also provided.