Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Reginald M. Gorczynski0
Date of Patent
April 17, 2007
0Patent Application Number
104165100
Date Filed
November 22, 2001
0Patent Citations Received
Patent Primary Examiner
Patent abstract
A truncated form of the full-length, immunosuppression-inducing molecule, CD200, CD200tr, was expressed in CHO cells and the transduced cells used to produce mAbs to CD200tr. These mAbs detect simultaneous expression of full-length CD200 and CD200tr in LPS-stimulated dendritic cells (DCs). Moreover, CHO cells and DCs expressing CD200tr as well as soluble CD200tr are able to inhibit suppression of mixed leucocyte reactions in vitro which follows addition of the soluble form of CD200 (CD200:Fc) in culture, demonstrating that CD200tr is a physiological antagonist of CD200.
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