Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Chase C. Smith0
Krishna K. Murthi0
Date of Patent
June 12, 2007
0Patent Application Number
106513400
Date Filed
August 28, 2003
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:
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