US Patent 7230101 Synthesis of methotrexate-containing heterodimeric molecules

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US Patent 11998611 Cryptophycin antibody conjugates for the treatment of cancer

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Patent Inventor Names

Chase C. Smith0

Krishna K. Murthi0

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Patent abstract

The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

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Official Website

https://pdfpiw.uspto.gov/.piw?Docid=072301010

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