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Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
November 20, 2007
Patent Application Number
09800240
Date Filed
March 6, 2001
Patent Primary Examiner
Patent abstract
The present invention provides methods to characterize the structure, stability, and intersubunit interfaces between the matrix, capsid, and nucleocapsid domains of the Gag polyprotein during HIV capsid assembly and maturation. A method of screening for compounds that promote or inhibit viral assembly and maturation is disclosed. A novel mass spectrometry based approach to measure hydrogen/deuterium exchange profiles is also disclosed. Quantitative data resulted from these studies may lead to well defined capsid assembly assays that can be adapted for rapid antiviral drug screening.
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