Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
George N. Cox0
Mary S. Rosendahl0
Daniel H. Doherty0
Date of Patent
December 11, 2007
0Patent Application Number
102763580
Date Filed
May 16, 2001
0Patent Primary Examiner
Patent abstract
The present invention relates to novel methods for making and refolding insoluble or aggregated proteins having free cysteines in which a host cell expressing the protein is exposed to a cysteine blocking agent. The soluble, refolded proteins produced by the novel methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form PEGylated proteins.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
