US Patent 7306931 Method for refolding proteins containing free cysteine residues
Patent 7306931 was granted and assigned to Bolder Biotechnology on December, 2007 by the United States Patent and Trademark Office.
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Patent Inventor Names
Daniel H. Doherty0
George N. Cox0
Mary S. Rosendahl0
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Patent abstract
The present invention relates to novel methods for making and refolding insoluble or aggregated proteins having free cysteines in which a host cell expressing the protein is exposed to a cysteine blocking agent. The soluble, refolded proteins produced by the novel methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form PEGylated proteins.
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US Patent 07306931 Method for refolding proteins containing free cysteine residues US Patent 7306931 Method for refolding proteins containing free cysteine residues
Infobox
Patent Number
073069310
Patent Number
73069310
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Infobox
Is a
Current Assignee
Patent Jurisdiction
Patent Number
073069310
Date of Patent
December 11, 2007
0Patent Application Number
102763580
Date Filed
May 16, 2001
0Official Website
Patent Primary Examiner
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US Patent 07306931 Method for refolding proteins containing free cysteine residues
Infobox
Is a
Current assignee
Patent jurisdiction
Patent number
07306931
Date of patent
December 11, 2007
Patent application number
10276358
Date Filed
May 16, 2001
Patent primary examiner
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