Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Donna Elizabeth Davies0
Stephen Holgate0
Sarah M. Puddicombe0
Date of Patent
December 25, 2007
0Patent Application Number
111353390
Date Filed
May 24, 2005
0Patent Primary Examiner
Patent abstract
The present invention relates to the use of an air-liquid interface culture model using asthmatic bronchial epithelial cells, which exhibit impaired epithelial barrier function. It is proposed to use asthmatic epithelial cultures, in the absence of added Th2 or proinflammatory cytokines such as IL-13, as an in vitro model to screen for agents that can act to improve impaired asthmatic epithelial barrier function. Such agents may have therapeutic utility in asthma patients.
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