Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Minor Kumar Senthil0
Radhakrishnan Selvaraju Mullaiyur0
Chandiran Thakashinamoorthy0
Kaliyaperumal Palanivel0
Date of Patent
February 12, 2008
Patent Application Number
10564804
Date Filed
July 15, 2004
Patent Primary Examiner
Patent abstract
The present invention relates to an improved method for the manufacture of Isradipine, 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester. Which, involves reacting 2,1,3-benzoxadiazole-4-carboxaldehyde with methyl acetoacetate in the presence of acetic acid and piperidine in diisopropyl ether. To obtain the product 2-acetyl-3-benzofurazan-4-yl-acrylic acid methyl ester which is then reacted with isopropyl-β-aminocrotonate in ethanol at 25 to 35° C. to obtain the product.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
