US Patent 7329756 Process for the manufacture of Isradipine
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Patent Inventor Names
Chandiran Thakashinamoorthy0
Kaliyaperumal Palanivel0
Minor Kumar Senthil0
Radhakrishnan Selvaraju Mullaiyur0
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Patent abstract
The present invention relates to an improved method for the manufacture of Isradipine, 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester. Which, involves reacting 2,1,3-benzoxadiazole-4-carboxaldehyde with methyl acetoacetate in the presence of acetic acid and piperidine in diisopropyl ether. To obtain the product 2-acetyl-3-benzofurazan-4-yl-acrylic acid methyl ester which is then reacted with isopropyl-β-aminocrotonate in ethanol at 25 to 35° C. to obtain the product.
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US Patent 07329756 Process for the manufacture of Isradipine US Patent 7329756 Process for the manufacture of Isradipine
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Patent Number
07329756
Patent Number
7329756
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US Patent 07329756 Process for the manufacture of Isradipine
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Patent jurisdiction
Patent number
07329756
Date of patent
February 12, 2008
Patent application number
10564804
Date Filed
July 15, 2004
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