Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
March 24, 2009
Patent Application Number
11224580
Date Filed
September 12, 2005
Patent Citations Received
0
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Patent Primary Examiner
Patent abstract
The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
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