Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Zhao-Kui Wan0
Steven J. Kirincich0
Weixin Xu0
Yan-Ling Zhang0
Bruce C. Follows0
David V. Erbe0
Douglas P. Wilson0
Jinbo Lee0
...
Date of Patent
April 21, 2009
0Patent Application Number
110634750
Date Filed
February 23, 2005
0Patent Primary Examiner
Patent abstract
Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for example, 2-carboxyl, 3-carboxymethoxy, 5-aryl substituted thiophenes, can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.
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