Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
K. Dane Wittrup0
Balaji M. Rao0
Douglas A. Lauffenburger0
Date of Patent
August 4, 2009
0Patent Application Number
108948330
Date Filed
July 19, 2004
0Patent Citations Received
...
Patent Primary Examiner
Patent abstract
The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Rα). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2α using yeast surface display to generate mutants with increased affinity for IL-2Rα.
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