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US Patent 7569215 Mutant interleukin-2 (IL-2) polypeptides

Patent 7569215 was granted and assigned to Massachusetts Institute of Technology on August, 2009 by the United States Patent and Trademark Office.

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US Patent 12116400 Albumin variants and conjugates

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US Patent 12091441 Partial agonists of interleukin-2

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US Patent 12084484 Interleukin-2 agents and uses thereof

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US Patent 12006347 Superagonists and antagonists of interleukin-2

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US Patent 11981715 Tissue targeted immunotolerance with a CD39 effector

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US Patent 11976103 Interleukin-2 muteins for the expansion of T-regulatory cells

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US Patent 11976102 Interleukin-2 muteins for the expansion of T-regulatory cells

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US Patent 11965008 IL-2 muteins and uses thereof

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US Patent 11945852 IL-2 muteins and uses thereof

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US Patent 11786567 Compositions and methods for the treatment of type 1 diabetes

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US Patent 11779632 IL-2 muteins and uses thereof

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Patent Inventor Names

Balaji M. Rao0

Douglas A. Lauffenburger0

K. Dane Wittrup0

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Patent abstract

The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Rα). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2α using yeast surface display to generate mutants with increased affinity for IL-2Rα.

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US Patent 11692020 Cytokine fusion proteins, and their pharmaceutical compositions and therapeutic applications

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US Patent 11680090 Interleukin-2 fusion proteins and uses thereof

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Official Website

https://pdfpiw.uspto.gov/.piw?Docid=075692150

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US Patent 07569215 Mutant interleukin-2 (IL-2) polypeptides US Patent 7569215 Mutant interleukin-2 (IL-2) polypeptides

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Patent Number

075692150

Patent Number

75692150

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Is a

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Current Assignee

Massachusetts Institute of Technology

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

075692150

Date of Patent

August 4, 2009

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Patent Application Number

108948330

Date Filed

July 19, 2004

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Official Website

https://pdfpiw.uspto.gov/.piw?Docid=075692150

Patent Primary Examiner

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Website URL

https://pdfpiw.uspto.gov/.piw?Docid=07569215

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US Patent 07569215 Mutant interleukin-2 (IL-2) polypeptides

Infobox

Is a

Current assignee

Massachusetts Institute of Technology

Patent jurisdiction

United States Patent and Trademark Office

Patent number

07569215

Date of patent

August 4, 2009

Patent application number

10894833

Date Filed

July 19, 2004

Patent primary examiner

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