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US Patent 7622455 Methods for slowing familial ALS disease progression

Patent 7622455 was granted and assigned to Ionis Pharmaceuticals on November, 2009 by the United States Patent and Trademark Office.

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Patent attributes

Current Assignee

Ionis Pharmaceuticals

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

C. Frank Bennett0

Susan M. Freier0

Thomas P. Condon0

Date of Patent

November 24, 2009

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Patent Application Number

115261340

Date Filed

September 21, 2006

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Patent Citations Received

US Patent 11760999 RAAV-based compositions and methods for treating amyotrophic lateral sclerosis

US Patent 11859179 Methods of treating amyotrophic lateral sclerosis (ALS)

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US Patent 11852634 Use of AKT phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same

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US Patent 11667915 RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality

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Patent Primary Examiner

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Patent abstract

Methods for slowing disease progression in an individual suffering from familial ALS are provided. Also provided are methods of increasing the survival time of an individual suffering from familial ALS. These methods employ antisense oligonucleotides targeted to SOD1, for use in inhibiting the expression of SOD1 in the central nervous system of an individual suffering from familial ALS.

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