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US Patent 7678554 Nucleic acid shuffling

Patent 7678554 was granted and assigned to President and Fellows of Harvard College on March, 2010 by the United States Patent and Trademark Office.

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Current Assignee

President and Fellows of Harvard College

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

Date of Patent

March 16, 2010

Patent Application Number

10101461

Date Filed

March 19, 2002

Patent Citations Received

US Patent 12084663 Incorporation of unnatural amino acids into proteins using base editing

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US Patent 11999947 Adenosine nucleobase editors and uses thereof

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US Patent 12006520 Evaluation and improvement of nuclease cleavage specificity

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US Patent 11661590 Programmable CAS9-recombinase fusion proteins and uses thereof

7

US Patent 11912985 Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence

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US Patent 11920181 Nuclease profiling system

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US Patent 11932884 High efficiency base editors comprising Gam

10

Patent Primary Examiner

Patent abstract

Disclosed is a method of altering a nucleic acid. The method includes fragmenting a parent nucleic acid strand to generate nucleic acid fragments. At least a subset of the fragments are ligated to generate shuffled nucleic acid strands. A selected strand is identified from the shuffled nucleic acid strands for a criterion.

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