Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Luigi Grasso0
Kenneth W. Kinzler0
Philip M. Sass0
Nicholas C. Nicolaides0
Bert Vogelstein0
Date of Patent
April 13, 2010
0Patent Application Number
113609950
Date Filed
February 24, 2006
0Patent Primary Examiner
Patent abstract
Bacteria are manipulated to create desirable output traits using dominant negative alleles of mismatch repair proteins. Enhanced hypermutation is achieved by combination of mismatch repair deficiency and exogenously applied mutagens. Stable bacteria containing desirable output traits are obtained by restoring mismatch repair activity to the bacteria.
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