US Patent 7695969 Methods for generating hypermutable microbes
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Patent abstract
Bacteria are manipulated to create desirable output traits using dominant negative alleles of mismatch repair proteins. Enhanced hypermutation is achieved by combination of mismatch repair deficiency and exogenously applied mutagens. Stable bacteria containing desirable output traits are obtained by restoring mismatch repair activity to the bacteria.
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Patent Inventor Names
Bert Vogelstein0
Kenneth W. Kinzler0
Luigi Grasso0
Nicholas C. Nicolaides0
Philip M. Sass0
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US Patent 07695969 Methods for generating hypermutable microbes US Patent 7695969 Methods for generating hypermutable microbes
Infobox
Patent Number
076959690
Patent Number
76959690
Edits on 29 Apr, 2023
Golden AI
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Patent Jurisdiction
Patent Number
076959690
Date of Patent
April 13, 2010
0Patent Application Number
113609950
Date Filed
February 24, 2006
0Official Website
Patent Primary Examiner
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US Patent 07695969 Methods for generating hypermutable microbes
Infobox
Is a
Patent jurisdiction
Patent number
07695969
Date of patent
April 13, 2010
Patent application number
11360995
Date Filed
February 24, 2006
Patent primary examiner
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