US Patent 7759358 Oral bioavailable prodrugs
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Patent abstract
The invention is directed to forming duplex prodrugs that provide significant increase in the transdermal flux of drugs across human skin. The prodrugs are prepared by reacting a drug that can form an ester moiety with phosgene to form a carbonate. The drug can be an opiate or an opiate antagonist. When in contact with human skin, the duplex drug is biotransformed by enzymes or by hydrolysis into two drug molecules.
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Patent Inventor Names
Audra Lynn Stinchcomb0
Mohamed Omer Hamad0
Peter A. Crooks0
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US Patent 07759358 Oral bioavailable prodrugs US Patent 7759358 Oral bioavailable prodrugs
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Patent Number
077593580
Patent Number
77593580
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Official Website
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Patent Jurisdiction
Patent Number
077593580
Date of Patent
July 20, 2010
0Patent Application Number
108974280
Date Filed
July 23, 2004
0Official Website
Patent Primary Examiner
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US Patent 07759358 Oral bioavailable prodrugs
Infobox
Is a
Patent jurisdiction
Patent number
07759358
Date of patent
July 20, 2010
Patent application number
10897428
Date Filed
July 23, 2004
Patent primary examiner
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