Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
William D. Huse0
Ying Tang0
Daniel Broek0
Jeffry D. Watkins0
Peter Brooks0
Date of Patent
July 27, 2010
0Patent Application Number
120701460
Date Filed
February 15, 2008
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
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