Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Wylie W. Vale, Jr.0
Jean E. Rivier0
Marilyn H. Perrin0
Roland Riek0
Grace Christy Rani Royappa0
Date of Patent
January 11, 2011
0Patent Application Number
111998210
Date Filed
August 9, 2005
0Patent Primary Examiner
Patent abstract
The present invention relates to a method for identifying modulators of B1 G-protein coupled receptors. The present invention also relates to a method for identifying an antagonist or agonist of the corticotropin-releasing factor receptor 2 (CRFR2). The present invention also relates to a method for improving antagonists or agonists of CRFR2. The present invention also relates to the three-dimensional structure of CRFR2 as representative of the B1 GPCR subfamily and its use as a basis for rational drug design of antagonist or agonists of B1 GPCRs.
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