Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
February 15, 2011
Patent Application Number
12074056
Date Filed
February 29, 2008
Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides compositions or mixtures of antibodies capable of binding human EGFR. Antibody compositions with 3 or more antibodies showed synergy in reduction of proliferation of representative cancer cell lines. Advantageous results have also been obtained with a composition comprising two different chimeric anti-hEGFR antibodies which show a new mechanism of action based on rapid and efficient receptor internalisation, induction of terminal differentiation and subsequent tumour eradication in an animal model. The antibodies of the invention can be manufactured in one bioreactor as a polyclonal antibody.
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