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US Patent 7951925 Methods and compositions for gene inactivation

Patent 7951925 was granted and assigned to Sangamo Biosciences Inc. on May, 2011 by the United States Patent and Trademark Office.

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Patent abstract

Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.

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