Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ivan Ivanov0
Hans-Guenther Grigoleit0
Rumen Tsanev0
Rolf Gunther0
Genoveva Nacheva0
Date of Patent
July 5, 2011
Patent Application Number
11886853
Date Filed
October 5, 2005
Patent Primary Examiner
Patent abstract
The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity to the hIFN-ϝ receptor. The derivatives represent genetically modified variants of hIFN-ϝ where the C-terminal part of the molecule is either deleted or replaced with a polypeptide sequence of another human protein and a recombinant hIFN-ϝ inactivated by physical or chemical methods.
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