US Patent 7973133 Inhibitor of endogenous human interferon-gamma
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Patent abstract
The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity to the hIFN-ϝ receptor. The derivatives represent genetically modified variants of hIFN-ϝ where the C-terminal part of the molecule is either deleted or replaced with a polypeptide sequence of another human protein and a recombinant hIFN-ϝ inactivated by physical or chemical methods.
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Patent Inventor Names
Genoveva Nacheva0
Hans-Guenther Grigoleit0
Ivan Ivanov0
Rolf Gunther0
Rumen Tsanev0
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US Patent 07973133 Inhibitor of endogenous human interferon-gamma US Patent 7973133 Inhibitor of endogenous human interferon-gamma
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Patent Number
07973133
Patent Number
7973133
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US Patent 07973133 Inhibitor of endogenous human interferon-gamma
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Is a
Patent jurisdiction
Patent number
07973133
Date of patent
July 5, 2011
Patent application number
11886853
Date Filed
October 5, 2005
Patent primary examiner
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