Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
L. David Williams0
Mark G. P. Saifer0
Merry R. Sherman0
Michael S. Hershfield0
Susan J. Kelly0
Date of Patent
November 29, 2011
0Patent Application Number
127695700
Date Filed
April 28, 2010
0Patent Citations Received
Patent Primary Examiner
Patent abstract
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
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