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US Patent 8367805 Fc variants with altered binding to FcRn

Patent 8367805 was granted and assigned to Xencor on February, 2013 by the United States Patent and Trademark Office.

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Patent abstract

The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.

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