Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Henry Fechner0
Roger J. Hajjar0
Wolfgang Ch. Poller0
Date of Patent
March 26, 2013
0Patent Application Number
128113060
Date Filed
December 23, 2008
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to targeted RNAi for the treatment of heart failure by modulating defective cardiac Ca2+ homeostasis via decreasing expression or activity of phospholamban (PLB) using adeno-associated virus (AAV) transfection of cardiomyocytes. Methods for decreasing ventricular arrhythmias, as well as methods for overall improvement of survival from heart failure in subjects are also disclosed. Further, the present invention provides methods which can be used to diagnose susceptibility to treatment by RNAi, and includes pharmaceutical compositions, kits and vectors including an RNAi sequence.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
