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US Patent 8975232 Macrocyclic kinase inhibitors and uses thereof

Patent 8975232 was granted and assigned to President and Fellows of Harvard College on March, 2015 by the United States Patent and Trademark Office.

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Patent
Patent

Patent attributes

Current Assignee
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President and Fellows of Harvard College
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8975232
Patent Inventor Names
David R. Liu0
Ralph E. Kleiner0
Date of Patent
March 10, 2015
Patent Application Number
13812431
Date Filed
July 29, 2011
Patent Citations Received
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US Patent 12084663 Incorporation of unnatural amino acids into proteins using base editing
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US Patent 11920181 Nuclease profiling system
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US Patent 11932884 High efficiency base editors comprising Gam
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US Patent 11999947 Adenosine nucleobase editors and uses thereof
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US Patent 12077795 Method for biocatalytic protein-oligonucleotide conjugation
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US Patent 11912985 Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
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Patent Primary Examiner
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James H Alstrum-Acevedo
Patent abstract

The present invention provides macrocyclic compounds of Formula (I): pharmaceutically acceptable salts thereof; and pharmaceutical compositions thereof, wherein R1, R2, R3, R4, RE, RF, RG, RH, RI, f, g, h, n, and m are as defined herein. The present invention further provides methods of synthesizing these macrocyclic compounds, and methods of their use and treatment. Certain aspects of the present invention relate to modulation of kinase activity, and in the treatment of kinase-associated diseases or disorders.

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