Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
July 14, 2015
0Patent Application Number
131338830
Date Filed
December 9, 2009
0Patent Citations Received
Patent Primary Examiner
Patent abstract
A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-I with high affinity and a subset with unprecedented selectivity. Agents and methods for selective pharmacologic neutralization of MCL-I are provided for drug discovery and therapeutic uses, including use in overcoming the apoptotic resistance of cancer and other diseases associated with impaired cell death.
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