Patent 9289477 was granted and assigned to SELECTA BIOSCIENCES INC on March, 2016 by the United States Patent and Trademark Office.
Disclosed are synthetic nanocarrier compositions, and related methods, comprising MHC Class I-restricted and/or MHC Class II-restricted epitopes associated with undesired CD8+ T cell responses and immunosuppressants that provide tolerogenic immune responses against antigens that comprise the epitopes.