Patent 9504236 was granted and assigned to Kymab on November, 2016 by the United States Patent and Trademark Office.
The invention pertains to a transgenic non-human mammal which contains a chimeric immunoglobulin locus containing human variable region gene segments at an endogenous Ig locus operatively linked to non-human mammalian constant region genes, and methods to produce chimeric antibodies therefrom.