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US Patent 9572879 ROBO2 inhibitory compositions comprising SLIT2-binding extracellular domain of ROBO2

Patent 9572879 was granted and assigned to Boston Medical Center on February, 2017 by the United States Patent and Trademark Office.

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Patent abstract

Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression of chronic kidney disease and proteinuria based on unexpected roles for the SLIT-ROBO signaling pathway in the regulation of podocyte F-actin cytoskeleton and foot process structure in the kidney.

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