Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jun Hasegawa0
Daisuke Okajima0
Hirofumi Hamada0
Miki Yamaguchi0
Shu Takahashi0
Toshinori Agatsuma0
Date of Patent
December 26, 2017
0Patent Application Number
151871790
Date Filed
June 20, 2016
0Patent Citations Received
Patent Primary Examiner
Patent abstract
It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(═O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(═O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.
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