Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Clinton K. Matson0
Chandrasekar Venkataramani0
Thomas F. Kenney0
Date of Patent
March 19, 2024
0Patent Application Number
178364800
Date Filed
June 9, 2022
0Patent Citations
...
Patent Primary Examiner
Patent abstract
The present disclosure generally relates to methods of treating or preventing cancer by administering an MCL-1 inhibitor and an antibody-drug conjugate, and optionally one or more additional anti-cancer agents. In particular, the MCL-1 inhibitor can be a compound of formula (I), (II) or (III), or compound A. The antibody-drug conjugate can comprises an anti-Trop-2 antibody and an anti-cancer agent (e.g., SN-38). The combination therapy for treating cancer can have synergistic effect.
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