Patent 9957318 was granted and assigned to AbbVie Inc. on May, 2018 by the United States Patent and Trademark Office.
The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.