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US Patent RE49582 Therapeutic compounds and compositions

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 US Patent RE49582 Therapeutic compounds and compositions

Article

Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.

Infobox
Is a
Patent
Patent
0
Patent Applicant
Agios Pharmaceuticals
Agios Pharmaceuticals
0
Current Assignee
Agios Pharmaceuticals
Agios Pharmaceuticals
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
RE495820
Date of Patent
July 18, 2023
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Patent Application Number
171315620
Date Filed
December 22, 2020
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Patent Citations
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US Patent 7173025 Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents
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US Patent 7235664 Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use
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US Patent 7241759 Benzo[1,2,5]thiadiazole compounds
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US Patent 7288554 Ortho-substituted aryl amides for controlling invertebrate pests
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US Patent 7358262 Identification of genotype-selective anti-tumor agents
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US Patent 7452888 Quinoline derivatives and their use as 5-ht6 ligands
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US Patent 7524848 Diaza heterocyclic amide compounds and their uses
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US Patent 7572913 4-substituted piperidine derivatives
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US Patent 7595322 Heterocyclic sulfonamides as modulators of cardiac sarcomeres
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US Patent 7615553 Inhibitors of histone deacetylase
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US Patent 7820654 Pyrimidine compounds, process for their preparation and compositions containing them
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US Patent 7858782 Triazine derivatives and their therapeutical applications
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US Patent 7863444 4-aminopyrrolopyrimidines as kinase inhibitors
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US Patent 8058313 Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof
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US Patent 8133900 Use of bi-aryl meta-pyrimidine inhibitors of kinases
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US Patent 8258295 Triazine derivatives, compositions containing such derivatives, and methods of treatment of cancer and autoimmune diseases using such derivatives
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US Patent 8278038 Methods for the identification, assessment, and treatment of patients with cancer therapy
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US Patent 8465673 Humidity dependence improver for polymer film, polymer film, protective film for polarizer, retardation film, polarizer, and liquid crystal display device
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US Patent 8501953 PKM2 modulators for use in the treatment of cancer
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US Patent 8603469 Methods of treating cancer with human monoclonal antibodies against interleukin 8
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US Patent 8642660 Method for altering the lifespan of eukaryotic organisms
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US Patent 8652534 Compositions and methods for treatment of mammalian skin
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US Patent 8673891 Aminopyrazine derivative and medicine
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US Patent 8735392 Crystalline (8
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US Patent 8742119 Pyruvate kinase M2 modulators, therapeutic compositions and related methods of use
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US Patent 8785450 Therapeutic compounds and compositions
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US Patent 8877791 Inhibitors of pyruvate kinase and methods of treating disease
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US Patent 8883438 Method for diagnosing cell proliferation disorders having a neoactive mutation at residue 97 of isocitrate dehydrogenase 1
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US Patent 8889667 Therapeutic compounds and compositions
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US Patent 9115086 Therapeutic compositions and related methods of use
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US Patent 9150505 Prophylactic or therapeutic agent for diabetes or obesity
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US Patent 9193701 Pyruvate kinase activators for use in therapy
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US Patent 9199968 Therapeutic compounds and compositions
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US Patent 9221792 N-(4-(azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase M2 (PMK2) modulators
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US Patent 9328077 Bicyclic PKM2 activators
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US Patent 9404081 Pyruvate kinase activators for use in therapy
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US Patent 9434979 Methods and compositions for cell-proliferation-related disorders
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US Patent 9474779 Therapeutically active compositions and their methods of use
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US Patent 9487815 Means and methods for the determination of (D)-2-hydroxyglutarate (D2HG) or (D)-2-hydroxyadipic acid
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US Patent 9579324 Therapeutically active compounds and their methods of use
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US Patent 9662327 Phenyl and pyridinyl substituted piperidines and piperazines as inhibitors of IDH1 mutants and their use in treating cancer
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US Patent 9682080 Pyruvate kinase activators for use in therapy
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US Patent 9732062 Therapeutically active compounds and their methods of use
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US Patent 9980961 Pyruvate kinase activators for use in therapy
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US Patent 10029987 Therapeutic compounds and compositions
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US Patent 10202339 Therapeutic compounds and compositions
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US Patent 10632114 Pyruvate kinase activators for use in therapy
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US Patent 11234976 Methods of using pyruvate kinase activators
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US Patent 11254652 Crystalline forms of N-(4-(4-(cyclopropymethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide
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Patent Primary Examiner
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Alan D Diamond
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CPC Code
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Y02P 20/582
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C07D 215/40
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C07D 215/36
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C07D 277/68
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C07D 277/64
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C07D 271/12
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C07D 243/08
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C07D 241/20
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C07D 241/22
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C07D 239/42
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C07D 417/14
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C07D 417/12
0
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C07D 409/12
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C07D 407/12
0
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C07D 405/12
0
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C07D 403/12
0
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C07D 401/14
0
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C07D 401/12
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C07D 319/18
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C07D 295/192
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A61P 9/00
0
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A61P 9/10
0
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A61P 35/00
0
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A61K 31/5513
0
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A61K 31/497
0

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